• With the Confoscan 4 system you can conduct true in-vivo analysis of all of the cellular layers of the anterior parts of the eye with incredibly high magnification and fidelity.
  
• This imagery here to fore was only available with histologic analysis of dead tissue under a microscope.
  Consequently, the changes in living tissue structures can be documented with unheard of fidelity, this gives the practitioner unsurpassed diagnostic capabilities.
  
• The Layers of organic structures are scanned in real time, advanced software allows detailed analysis of all examinations.

Generally nearly all corneal layers are clearly visible through confocal microscopy:

• epithelial layer (50 µm)
• sub-epithelial nerve plexus
• stroma (400 µm)
• endothelium (30 µm)
  

Corneal pathologies

• Polymegethism, pleomorphism
• Keratoconus
• Cornea Guttata
• Fuchs’ endothelial dystrophy
• Schnyder’s crystalline dystrophy
• Granular dystrophy
• Megalocornea in congenital glaucoma
• Acanthamoeba keratitis
• Trauma, ulcers and infections
• Fungal hyphae
• Corneal deposits
• Contact lens induced corneal changes

Other clinical applications

• Morphological analysis at a research level, including 2D/3D keratocites density assessment
• Endothelial cell analysis, even in presence of corneal opacities
• Morphological study of corneal haze
• Pre and post PRK evaluation
• Pre and post Lasik evaluation
• Pre and post PKP ad DLKP interface evaluation
• Optical pachymetry and location of corneal structures
• Cataract surgery
• Ex vivo applications

Confoscan 4 Main Users

• All Corneal Pathologists: Confoscan 4 enables the Doctor to see in real-time all corneal layers in order to evaluate the corneal status from Epithelium to Endothelium.


• Refractive Surgeons: Confoscan 4 enables the Doctor to see the real amount of pachymetry of the single corneal layer and the situation of each corneal layer after refractive procedure (PRK, Lasik, PTK).


• Cataract Surgeons: Confoscan 4 enable the Doctor to see the real situation of the endothelium pre and post cataract surgery.


• University Researchers: Confoscan 4 enable the complete study of the cornea like an histological examination in order to evaluate the results of any new research directly in the human cornea.

High Precision - thanks to the fully automated alignment and scan time is optimised (350 images in ~15 sec/exam), minimum patient co-operation is required, no contact examinations can be performed, assuring high patient comfort; nine internal fixation points help the patient keep the stability of fixation thus increasing the performance of the device, adding the possibility to store and analyse automatically different corneal areas.

Full Cornea Scan - Fully-automatic, Semi-automatic, Manual Mode and customisable exams are available with the possibility to choose the corneal layers to be scanned - Endothelium, Epithelium or Full cornea - in one unique exam. CS4 gives the user the possibility to recognize the early findings of any corneal disease for pre surgery check/schedule and post surgery follow up; early signs of rejection or other abnormal corneal reactions are detectable to determine the best course of therapy.

Opacity Error Free - Thanks to the confocal principle now the corneal opacities don’t represent a problem for endothelial microscopy and pachymetry. High quality imaging through corneal haze and opacities even with the non-contact endothelial microscopy functionality. The new Z-Ring increases the stability of the exam and the reliability of the Z-Scan reference for accurate full thickness optical pachymetry; CS4 in this way has the unique ability to define with high precision the position of any corneal structure and opacity, in terms of corneal layers involved, with respect to the endothelium and epithelium.

Extra Large Measurement Areas - With the new 20x probe it is possible to image a wide field of view counting up to 1000 cells per exam. The automatic endothelial analysis is reliable, thanks to the high number of cells counted, displaying the density plus polimegathism and pleomorphism indexes, giving more objective data for medical assessments.